A knowledgebase of the human Alu repetitive elements
نویسندگان
چکیده
منابع مشابه
Alu Elements and Human Disease
The Alu element Methylation of Alu Repeats DNA Demethylation Mechanism of Retrotransposition Alu elements and Disease Conclusion and Outlook Endnotes
متن کاملEstimating the retrotransposition rate of human Alu elements.
Mobile elements such as Alu repeats have substantially altered the architecture of the human genome, and de novo mobile element insertions sometimes cause genetic disorders. Previous estimates for the retrotransposition rate (RR) of Alu elements in humans of one new insertion every approximately 100-125 births were developed prior to the sequencing of the human and chimpanzee genomes. Here, we ...
متن کاملThe possible roles of human Alu elements in aging
The huge amount of knowledge about the organization and functions of genome structural units accumulated through genome research allows us to examine cell aging processes in detail and to test existing hypotheses of aging. One of the hypothesis currently of interest is that instability of the cell genome is one of the main causes of aging (Vijg and Suh, 2013). Putative causes of genome instabil...
متن کاملInvasion of the human albumin-alpha-fetoprotein gene family by Alu, Kpn, and two novel repetitive DNA elements.
The human albumin-alpha-fetoprotein genomic domain contains 13 repetitive DNA elements randomly distributed throughout the symmetrical structures of these genes. These repeated sequences are located at different sites within the two genes. The human albumin gene contains five Alu elements within four of its 14 intervening sequences. Two of these repeats are located in intron 2, and the remainin...
متن کاملDevelopment of two highly sensitive forensic sex determination assays based on human DYZ1 and Alu repetitive DNA elements.
Sex determination is a critical component of forensic identification, the standard genetic method for which is detection of the single copy amelogenin gene that has differing homologues on the X and Y chromosomes. However, this assay may not be sensitive enough when DNA samples are minute or highly compromised, thus other strategies for sex determination are needed. In the current research, two...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2016
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2016.01.010